Hepatic zonation of mRNAs encoding drug-metabolizing enzymes in Ctnnb1 wild-type (wt) and knockout (ko) mice
Gene | Zonation of Gene Expression (Perivenous Hepatocytes, % of Periportal) | ||
|---|---|---|---|
| Ctnnb1 Wild-type | Ctnnb1 Knockout | ||
| Cyp1a2 | 821 ± 72*** | 160 ± 24 | |
| Cyp2b10 | 319 ± 82* | 121 ± 39 | |
| Cyp2c | 964 ± 44*** | 302 ± 113 | |
| Cyp2e1 | 1736 ± 151*** | 204 ± 11** | |
| Cyp2f2 | 4 ± 1** | 83 ± 10 | |
| Cyp3a | 169 ± 36 | 35 ± 9* | |
| GSTm2 | 906 ± 117** | 105 ± 23 | |
| GSTm3 | 1579 ± 350** | 92 ± 29 | |
| GSTm6 | 162 ± 22 | 86 ± 26 | |
Mean [n = 3 (wt); n = 4 (ko)] ± S.E.M. are given. Significant differences in zonal gene expression between wild-type and Ctnnb1 knockout mice are indicated by asterisks: *** p < 0.001, * p < 0.05, and ** p < 0.01 (Student's t test).