TABLE 1

Outlines of stable isotope coadministration studies of PNU96391 in rats

Study No.	Compound Dosed	Dosing Route	Dose	Biological Samples Analyzed
			mg/kg
1^a	PNU96391	p.o.	10	Blood plasma (jugular vein) and urine
	[¹³C,²H₃]PNU96391	p.o.	10
2^b	PNU96391	i.v.	5	Blood plasma (portal and jugular veins) and urine
	[¹³C,²H₃]PNU96391	p.o.	10
3^c	M1	i.v.	5	Blood plasma (jugular vein) and urine
	[¹³C,²H₃]PNU96391	p.o.	10

↵ a Each animal (n = 2) was coadministered PNU96391 (10 mg/kg p.o.) with [¹³C,²H₃]PNU96391 (10 mg/kg p.o.).
↵ b Each animal (n = 4) was coadministered PNU96391 (5 mg/kg i.v.) with [¹³C,²H₃]PNU96391 (10 mg/kg p.o.).
↵ c Each animal (n = 4) was coadministered M1 (5 mg/kg i.v.) with [¹³C,²H₃]PNU96391 (10 mg/kg p.o.).