TABLE 3

Total B/P at 0.5 and 2 h for compounds in FVB, Mdr1a/1b(–/–),(–/–), Bcrp(–/–), and Mdr1a/1b(–/–),(–/– )Bcrp(–/–) mice after s.c. administration

Data are presented as mean ± S.D. from three to five male mice.




FVB

Mdr1a/1b(–/–),(–/–)

Bcrp(–/–)

Mdr1a/1b(–/–),(–/–)Bcrp(–/–)
0.5 h
    Flavopiridol 0.42 ± 0.06 0.71 ± 0.07*** 0.55 ± 0.05* 3.11 ± 0.59***
    Imatinib 0.02 ± 0.00 0.09 ± 0.02*** 0.02 ± 0.00 0.58 ± 0.18**
    PF-407288 0.01 ± 0.001 0.02 ± 0.005* 0.02 ± 0.002** 0.03 ± 0.004**
    Prazosin 0.17 ± 0.01 0.31 ± 0.07* 0.23 ± 0.06 1.04 ± 0.20**
2 h
    Flavopiridol 0.92 ± 0.07 1.45 ± 0.39 1.22 ± 0.09** 6.34 ± 0.88***
    Imatinib 0.02 ± 0.00 0.11 ± 0.03** 0.02 ± 0.01 1.55 ± 0.77*
    PF-407288 0.02 ± 0.003 0.02 ± 0.004 0.02 ± 0.003 0.03 ± 0.004*
    Prazosin
0.33 ± 0.03
0.58 ± 0.08**
0.37 ± 0.01
1.73 ± 0.26***
  • * vs. FVB, P < 0.05.

  • ** vs. FVB, P < 0.01.

  • *** vs. FVB, P < 0.001.