TABLE 2

Plasma exposure of saxagliptin and M2 in preclinical species after oral administration

Species
Dose
AUC0-ta
Saxagliptin
M2
mg/kg μg · h/ml
Ratb 2 0.19 0.06
20 1.36 0.47
200 18.01 4.46
Dog (n = 3/dose) 1 1.41 ± 0.36 1.15 ± 0.57
5 8.69 ± 1.28 12.07 ± 1.03
25 46.50 ± 26.05 17.47 ± 0.37
Monkey (n = 3/dose) 5 2.33 ± 0.91 13.14 ± 2.45
25
13.77 ± 2.13
88.38 ± 10.37

  • ↵ a Calculated from time 0 to the time of last measurable concentration, ranging between 8 and 24 h.

  • ↵ b AUC is the result of the composite data of total of 10 rats; hence S.D. is not given (see Materials and Methods for the details of the study design).