Saxagliptin predicted human CL and CLr, oral CL/F and CLr/F, and Vss values obtained from scaling of in vivo preclinical data
The actual observed mean plasma and renal oral clearance values are also shown.
Method | Pharmacokinetic Parameters | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| CL | CLr | CL/F | CLr/F | Vss | |||||
| ml/min/kg | l/kg | ||||||||
| SA | 3.4 | 1.9 | 5.1 | 2.8 | 0.8 | ||||
| SIT | 11.5 | 15.0 | 2.7 | ||||||
| Observed |
|
| 17.4 | 2.5 |
| ||||
SA, simple allometry; SIT, species invariant time method.