Predicted and observed human pharmacokinetic parameters of saxagliptin at 1 mg/kg oral dose
Prediction -fold errors are also included.
Pharmacokinetic Parameter | Observed | Predicted | Prediction -Fold Error |
|---|---|---|---|
| AUC0-∞ (ng/ml × h) | 1110 | 958 | 1.2 |
| Cmax (ng/ml) | 270 | 163 | 1.7 |
| C12 h (ng/ml)a | 14.4 | 15.1 | 1.1 |
| t1/2 (h) | 2.7 | 2.7 | 1.0 |
↵ a C12 h values reflect the concentration at 12 h postdose (the last measurable concentration at this dose).