Ester conversion and permeability of latanoprost in cHCE and excised rabbit cornea (dosed as either ester or acid)
Data are presented as the mean of triplicates ± S.D.
Compound Dosed | Papp | ||
|---|---|---|---|
| Measured as the Ester | Measured as the Acid | ||
| 10-6 cm/s | |||
| Latanoprost in cHCE | 0.8 ± 0.3 | 18.5 ± 2.3 | |
| Latanoprost acid in cHCE | N.A. | 0.4 ± 0.2 | |
| Latanoprost in cornea | 0a | 13.8 ± 2.7 | |
| Latanoprost acid in cornea | N.A. | 0.4 ± 0.1 | |
N.A., not applicable.
↵ a Latanoprost was not detected in the receiver chamber.