Rat Plasma/Microsomes Fraction Unboundb
| Rat || Human |
| Amide 4 || 414/3.54 || 0.030/0.93 || >90 || >90 |
MW, molecular weight.
↵ a LogP values were calculated using ACD software (Advanced Chemical Development, Inc.).
↵ b Fraction unbound estimates in rat plasma and rat liver microsomes were obtained using in silico models developed at Pfizer as described previously with human liver microsomes (Gao et al., 2008). Literature free fraction of indomethacin in rat plasma is 0.040 (Dawidowicz et al., 2008), indicating high confidence in the in silico predictions.