P450 isozymes responsible for metabolic turnover of indomethacin amides 1 to 3 in human liver microsomes
Indomethacin amide 4 was not tested because it was resistant to metabolic turnover.
Compound | % Inhibition of Substrate Depletion | ||
|---|---|---|---|
| Microsomes + Ketoconazole | Microsomes + Quinidine | ||
| Amide 1 | 96 | <5 | |
| Amide 2 | 100 | 35 | |
| Amide 3 | 100 | 28 | |