Compound | Dose | Route | Cmax | Tmax | CLp | Vdss | AUC0—∞ | T1/2 | F |
---|---|---|---|---|---|---|---|---|---|
mg/kg | ng/ml | h | ml/min/kg | l/kg | ng · h/ml | h | % | ||
Amide 1 | 1.0 | i.v. | 155 ± 41.5 | 5.3 ± 1.2 | 114 ± 35.0 | 0.6 ± 0.1 | |||
5.0 | p.o. | N.C. | N.C. | N.C. | N.C. | ||||
Amide 2 | 1.0 | i.v. | 26.0 ± 9.40 | 2.3 ± 1.1 | 699 ± 240 | 1.1 ± 0.3 | |||
5.0 | p.o.a | 57.0 | 3.0 | 677 | 20 | ||||
Amide 3 | 1.0 | i.v. | 39.2 ± 4.50 | 2.0 ± 0.4 | 430 ± 49.0 | 1.0 ± 0.3 | |||
5.0 | p.o. | 120 ± 55.8 | 1.2 ± 0.7 | 828 ± 490 | 38.5 | ||||
Amide 4 | 1.0 | i.v. | 31.0 ± 7.00 | 0.7 ± 0.2 | 562 ± 150 | 1.4 ± 0.4 | |||
5.0 | p.o. | 154 ± 42.1 | 1.0 ± 0.8 | 1060 ± 167 | 37.6 | ||||
Indomethacinb | 1.0 | i.v. |
|
| 0.51 ± 0.04 | 0.19 ± 0.03 |
| 4.6 ± 1.0 |
|