Physicochemical description of drugs included in the study
Values of logD7.4 (ACDLogD pH 7.4) and pKa (ACDpKa) were calculated using ACDlabs databases (version 9.03; Advanced Chemistry Development Inc., Toronto, ON, Canada).
Compound | Ion Class | ACDlogD7.4 | ClogP |
|---|---|---|---|
| Diazepam | Neutral | 2.96 | 2.96 |
| Gabapentin | Zwitterion | -1.31 | -0.66 |
| Indomethacin | Acid | -0.33 | 4.18 |
| Paroxetine | Base | 0.97 | 4.24 |
| Rimonabant | Neutral | 6.14 | 6.47 |
| Thioridazine | Base | 3.85 | 6.00 |