TABLE 2

Estimates of V_u,brain and variance components (expressed as percentage of total variability) for model compounds

Analysis was repeated for the cassette experiment with six slices from each of three rats on 3 days (n = 54 slices). Mean values of compound recovery are given with the S.D. calculated on the linear scale

Compound	V_u,brain Mean^a	V_u,brain 95% CIR^b	Compound Recovery	Variance Components^c
Compound	V_u,brain Mean^a	V_u,brain 95% CIR^b	Compound Recovery					Days	Rats	Slices	Analytical
	ml · brain^-1		%	% total variability
Diazepam	19.6	1.132	94.5 ± 3.2	10.5	2.5	37.4	49.7
Gabapentin	4.48	1.484	102 ± 9.5	30.0	12.7	0	57.3
Indomethacin	13.0	1.136	88.2 ± 8.8	13.1	23.4	36.5	26.9
Paroxetine	862	1.149	97.1 ± 4.6	18.7	0.0	46.2	35.1
Thioridazine	2617	1.203	103 ± 8.6	9.7	0.0	51.1	39.1

↵ a The mean is a geometric mean, the antilog of the mean of the logs.
↵ b The 95% CIR is the confidence interval ratio; the 95% confidence interval is the ratio of the mean divided by the CIR to the mean multiplied by the CIR. The tabulated CIR refers to a single analysis of a single slice.
↵ c Total variability is defined as the variability (variance) of a single observation. It is the sum of all the variance components.