Prediction of CYP1A2 inhibition by thiabendazole
Combination | Mechanism | Predicted Mean AUC -Fold Increase | Observed Clinical DDI -Fold Increase in AUC |
|---|---|---|---|
| Thiabendazole/thiabendazole | MBI | 22.51 | 1.0 |
| Thiabendazole/caffeine | Competitive | 1.23 | 1.6 |
| MBI | 11.40 | ||
| Thiabendazole/theophylline | Competitive | 1.56 | 2.91 |
|
| MBI | 5.65 |
|