TABLE 2
Binding constants for various ligands to cytochrome 2A6 versus cytochrome 2A13
Values are the average of duplicate measurements.
Ligand | Structure | KD | KD 2A6/KD 2A13 | ||
|---|---|---|---|---|---|
| 2A6 | 2A13 | ||||
| μM | |||||
| Coumarin |
| 3.1 | 2.7 | 1.1 | |
| Nicotine |
| 103. | 22. | 4.7 | |
| 8-Methoxypsoralen |
| 1.3 | <0.10 | 13 | |
| Phenethyl isothiocyanate |
| 6.2 | 0.43 | 14. | |
| 2′-Methoxyacetophenone |
| 74. | 1.0 | 74. | |