The composition of conjugative metabolites of motesanib in microsomes across species
Cofactor | Percentage of Metabolite Formationa | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Metabolite | Rat | Mouse | Dog | Monkey | Human | |||||
| UDP-GA | M1 | 20.5 | 6.6 | 13.6 | 28.5 | 67.7 | ||||
| UDP-glucose | Mb | 5.1 | 9.3 | 3.1 | 46.2 | ND | ||||
| UDP-N-acetylglucosamine | Mc | ND | ND | ND | 24.4 | ND | ||||
ND, not detected.
↵ a Results obtained by HPLC with a β-RAM radiometric detector. Percentages represent mean relative amount of conjugative metabolites M1, Mb, and Mc formed in microsomal incubations (n = 2 for each species) using 10 μM motesanib and 1 mg/ml microsomal protein incubated in the presence of cofactor (2 mM) at 37°C for 30 min.