Effect of leukotriene derivatives on E217βG uptake by wild-type and K332L mutant MRP1
The values shown represent the means (±S.D.) of IC50 values obtained in three or four independent experiments (number shown in parentheses).
E217βG Uptake IC50 | |||
|---|---|---|---|
| Leukotriene Derivative | Wild-type | K332L | |
| μM | μM | ||
| LTC4 | 0.1 ± 0.03 (3) | 2.5 ± 0.5 (3)a | |
| LTD4 | 4.3 ± 0.4 (3) | 4.2 ± 2.3 (3) | |
| LTF4 | 3.7 ± 0.1 (4) | 15.3 ± 7.3 (4)a | |
↵ a Significantly different from IC50 in wild-type MRP1 (p < 0.01).