Binding (S.D.) of spiked BUD to rat plasma and tissues
Brain | Kidney | Liver | Lung | Plasma | |
|---|---|---|---|---|---|
| % bound | % bound | % bound | % bound | % bound | |
| In vitro | |||||
| BUD (8 nM) | 96.1 (1.2) | 97.6 (1.2) | 98.4 (0.4) | 94.0 (1.1) | 96.1 (0.7) |
| BUD (800 nM) | 97.0 (0.3) | 98.7 (0.2) | 99.1 (0.2) | 96.6 (1.2) | 96.6 (0.8) |
| Des-CIC (8 nM) | 99.5 (0.3) | 99.6 (0.2) | 99.6 (0.3) | 98.1 (0.3) | 98.4 (0.3) |
| Des-CIC (800 nM) | 99.2 (0.5) | 99.4 (0.2) | 99.5 (0.1) | 98.1 (0.6) | 98.8 (0.4) |
| Ex vitro after infusion | |||||
| BUD (see Table 2) | 94.2 (1.3) | 97.4 (1.1) | 98.0 (0.5) | 96.2 (1.0) | 92.6 (1.8) |
| des-CIC (see Table 2) | 98.8 (0.4) | 99.6 (0.3) | 99.2 (0.6) | 99.4 (0.2) | 98.2 (1.1) |