TABLE 2

R B and f u and f B for each compound in female SD rats

fu and RB values were measured and fB was calculated by dividing fu by RB. Each value is expressed as mean ± S.E. of triplicate determinations.

Compound
fu
RB
fB
Pravastatin 0.509 ± 0.047 0.769 ± 0.038 0.662 ± 0.069
Pitavastatin 0.00642 ± 0.00174 0.539 ± 0.012 0.012 ± 0.003
Rosuvastatin 0.0525 ± 0.0058 0.631 ± 0.029 0.083 ± 0.010
Valsartan 0.0100 ± 0.0008 0.702 ± 0.059 0.014 ± 0.002
Olmesartan 0.00861 ± 0.00067 0.843 ± 0.02 0.010 ± 0.001
Candesartan 0.00651 ± 0.00150 0.578 ± 0.02 0.011 ± 0.003
Temocaprilat 0.0639 ± 0.0099 0.780 ± 0.055 0.082 ± 0.014
Enalaprilat 0.420 ± 0.003 0.751 ± 0.010 0.559 ± 0.008
Benazeprilat 0.245 ± 0.076 0.670 ± 0.042 0.366 ± 0.116
PCG 0.454 ± 0.085 0.664 ± 0.014 0.684 ± 0.129
Ceftizoxime 0.654 ± 0.070 0.767 ± 0.032 0.853 ± 0.098
Cefmetazole
0.598 ± 0.063
0.691 ± 0.021
0.865 ± 0.095