Tissue uptake clearance of drugs obtained from integration plot analyses
CLuptake, p (milliliters per minute per gram of tissue) obtained from the slope of an integration plot was converted to CLuptake, B (milliliters per minute per kilogram) using the weight of rat liver (38.3 g of liver/kg b.wt.) and kidney (7.27 g of kidney/kg b.wt.), and RB values. Each value is expressed as mean ± computer-calculated S.D. of three to four rats.
Compound | CLuptake, B | ||
|---|---|---|---|
| Liver | Kidney | ||
| ml/min/kg | |||
| Pravastatin | 57.3 ± 9.4 | 27.1 ± 3.5 | |
| Pitavastatin | 63.7 ± 1.3 | 13.9 ± 0.3 | |
| Rosuvastatin | 66.1 ± 9.5 | 20.9 ± 1.2 | |
| Valsartan | 33.3 ± 3.6 | 3.50 ± 0.53 | |
| Olmesartan | 13.7 ± 0.3 | 2.46 ± 0.52 | |
| Candesartan | 6.18 ± 1.52 | 0.932 ± 0.206 | |
| Temocaprilat | 45.6 ± 0.9 | 20.5 ± 0.7 | |
| Enalaprilat | 4.54 ± 0.75 | 18.7 ± 1.8 | |
| Benazeprilat | 16.0 ± 2.0 | 29.2 ± 0.8 | |
| PCG | 49.7 ± 3.3 | 44.8 ± 11.5 | |
| Ceftizoxime | 2.89 ± 0.03 | 12.3 ± 1.1 | |
| Cefmetazole | 37.6 ± 1.2 | 47.2 ± 0.3 | |