Parameters | Day 1 of 7 | Day 7 | Day 1 of 14 | Day 14 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean ± S.D. | CV | Mean ± S.D. | CV | Mean ± S.D. | CV | Mean ± S.D. | CV | |||||
% | % | % | % | |||||||||
λ (min-1) | 0.0094 ± 0.0017 | 17.89 | 0.0079 ± 0.0014 | 18.24 | 0.0083 ± 0.0024 | 28.57 | 0.0084 ± 0.0013 | 15.24 | ||||
AUC (μg · min · ml-1)a,b | 114.31 ± 10.02 | 8.77 | 171.33 ± 17.81 | 10.40 | 114.28 ± 20.38 | 17.84 | 182.44 ± 28.60 | 15.68 | ||||
Cmax (μg/ml)a,b | 1.43 ± 0.15 | 10.58 | 1.92 ± 0.17 | 8.93 | 1.50 ± 0.25 | 16.61 | 1.99 ± 0.17 | 8.42 | ||||
tmax (min) | 20.00 | 20.00 | 20.00 | 20.00 | ||||||||
Cl/F (l · kg-1 · min-1)a,b | 176.08 ± 15.27 | 8.67 | 117.81 ± 12.44 | 10.56 | 180.07 ± 34.33 | 19.06 | 111.91 ± 17.52 | 15.65 | ||||
Va/F (l/kg)b | 19.41 ± 4.30 | 22.16 | 15.42 ± 3.42 | 22.18 | 22.78 ± 5.25 | 23.03 | 13.61 ± 3.05 | 22.42 | ||||
Vss/F (l/kg)a,b | 17.26 ± 2.32 | 13.44 | 14.15 ± 1.83 | 12.93 | 22.73 ± 5.18 | 22.81 | 13.61 ± 3.07 | 22.53 | ||||
t1/2λ (min) | 76.07 ± 12.90 | 16.96 | 90.53 ± 16.33 | 18.04 | 90.52 ± 29.00 | 32.03 | 84.03 ± 13.60 | 16.19 | ||||
AUMC (μg · min2 · ml-1)a,b | 8717.6 ± 1416.2 | 16.25 | 20,707.8 ± 3775.1 | 18.23 | 12,094.3 ± 3755.4 | 31.05 | 21,574.6 ± 3890.5 | 18.03 | ||||
MRT (min) | 98.38 ± 13.64 | 13.86 | 120.51 ± 14.26 | 11.83 | 79.02 ± 4.99 | 6.32 | 118.69 ± 14.15 | 11.92 | ||||
MAT (min) | 71.42 | 93.55 | 52.06 | 91.73 | ||||||||
F (%) | 97.75 |
| 146.51 |
| 97.73 |
| 156.01 |
|