Dose | |||||||
---|---|---|---|---|---|---|---|
1 mg of Hb/kg | 10 mg of Hb/kg | 200 mg of Hb/kg | 1400 mg of Hb/kg | ||||
t1/2β (h) | 3.1 ± 3.1 | 3.6 ± 1.3 | 7.2 ± 3.1 | 18.8 ± 1.3 | |||
AUC (hr · % dose/ml) | 29.4 ± 7.2 | 32.9 ± 3.8 | 134 ± 42 | 829 ± 38 | |||
Clearance (ml/h) | 3.40 ± 0.1 | 3.04 ± 0.1 | 0.74 ± 0.1 | 0.12 ± 0.1 | |||
V1 (ml) | 2.35 ± 0.2 | 2.43 ± 0.3 | 2.24 ± 0.2 | 1.75 ± 0.6 |