Pharmacokinetic parameters of HbV after administration of 125I- and 3H-HbV in mice and rats
All mice and rats received a single injection of 125I-HbV or 3H-HbV at a dose of 1400 mg of Hb/kg containing 5% rHSA. At each time after the injection of 125I-HbV or 3H-HbV, a blood sample was collected from the inferior vena cava (mice) or from the tail vein (rats), and plasma was obtained. Each parameter was calculated by MULTI using a two-compartment model. Values are mean ± S .D. (n = 3–6).
Mice | Rats | |||||
|---|---|---|---|---|---|---|
| 125I-HbV | 3H-HbV | 125I-HbV | 3H-HbV | |||
| t1/2β (h) | 18.8 ± 1.3 | 19.9 ± 0.9 | 30.6 ± 4.0 | 30.9 ± 4.7 | ||
| AUC (hr · % dose/ml) | 829 ± 28 | 899 ± 44 | 210 ± 23 | 247 ± 22 | ||
| Clearance (ml/h) | 0.12 ± 0.04 | 0.11 ± 0.03 | 0.46 ± 0.04 | 0.41 ± 0.02 | ||
| V1 (ml) | 1.75 ± 0.6 | 1.71 ± 0.1 | 10.9 ± 0.2 | 10.2 ± 2.0 | ||