Brain CYP1B1, CYP2D6, CYP2J2, CYP2U1, and CYP46A1 protein immunocytochemical staining in human frontal lobe, hippocampus, and cerebellum
Brain Region and Cell Type | CYP2D6 | CYP1B1 | CYP2J2 | CYP2U1 | CYP46A1 | ||
|---|---|---|---|---|---|---|---|
| Frontal cortex | |||||||
| Cell body of the neurons | + | - | - | + | +++ | ||
| Glial cells | Astrocytes [glia limitans] | ++ [+++] | + [+++] | +++ [+] | +++ [+++] | -[-] | |
| Oligodendrocytes | - | - | - | - | - | ||
| Microglia | - | +++ | - | - | - | ||
| Hippocampus | |||||||
| Neurons | Dentate gyrus granular layer | - | + | ++ | - | +++ | |
| CA1-3 pyramidal cells | ++ | - | +++ | ++ | +++ | ||
| CA4 pyramidal cells | ++ | - | +++ | ++ | +++ | ||
| Glial cells | Astrocytes [glia limitans] | ++ [+++] | + [+++] | +++ [+] | +++ [N.A.] | -[-] | |
| Oligodendrocytes | - | - | - | - | - | ||
| Microglia | - | +++ | - | - | - | ||
| Cerebellum | |||||||
| Neurons and neuronal processes | Purkinje cells | +++ | - | + | - | +++ | |
| Cell body of the granule cell | - | - | + | ++ | - | ||
| Glomeruli | + | +++ | + | - | ++ | ||
| Glial cells | Molecular layer (astrocytes) | ++ | ++ | +++ | +++ | - | |
| White matter (astrocytes) | +++ | + | + | +++ | - | ||
| White matter (oligodendrocyte) | - | - | - | - | - | ||
|
| White matter (microglia) | - | +++ | - | - | - | |
+++, strong; ++, moderate; +, weak; -, no staining; N.A., not available.