TABLE 1
Model parameters for MDZ used in the simulations
Parameter | Valuesa |
|---|---|
| Ka (h-1) | 1.2 |
| Vc (liters) | 42.9 |
| Vp (liters) | 88.4 |
| CLr (l/h) | 0.06 |
| CLint, 3A (l/h) | 439 |
| CLint, non3A (l/h) | 36 |
| Vmax, 3A (mg/h)b | 2549 |
| Vmax, non3A (mg/h)b | 254 |
| Vmax, GW, 3A (mg/h)b | 2549 |
| Km (mg/l)b | 5.8 |
| f u | 0.04 |
| VGW (liters) | 0.25 |
| VPV (liters) | 0.07 |
| VLIV (liters) | 2.8 |
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↵ a Adapted from Chien et al., 2006.
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↵ b Km was estimated using human liver microsome in house. Vmax, 3A was estimated by CLint 3A × Km. Vmax, non3A was estimated as approximately
of Vmax, 3A. Vmax, GW, 3A was assumed to be the same as Vmax, 3A.