Simulation scenarios used in the study
Simulation Scenario | References |
|---|---|
| DTZ IR, 60 mg p.o., single dose | Hermann et al., 1983 |
| DTZ IR, 60 mg, for 5 doses | Backman et al., 1994 |
| DTZ IR, 60 mg, for 5 doses; MDZ, 3.5 mg i.v. infusion over 2 min, before DTZ administration and after the last dose of DTZ | N.A. |
| DTZ IR, 60 mg, for 5 doses; MDZ, 15 mg p.o., before DTZ administration and after the last dose of DTZ | Backman et al., 1994 |
| DTZ SR (Cardizem SR), 120 mg p.o., single oral dose | Lefebvre et al., 1994 |
| DTZ SR (Cardizem SR), 120 mg p.o., twice daily for 6 days | Lefebvre et al., 1994 |
| DTZ SR (Cardizem SR), 120 mg p.o., twice daily for 6 days; MDZ, 0.05 mg/kg i.v. infusion over 2 min, before and on day 6 of DTZ administration | Clinical study |
| DTZ SR (Cardizem SR), 120 mg p.o., twice daily for 6 days; MDZ, 4 mg p.o., before and on day 6 of DTZ administration | Clinical study |
N.A., not available.