Oral MDZ | Intravenous MDZ | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Before | After | p | Before | After | p | |||||
Cmax (mg/l) | 15.8 ± 2.8 | 41.3 ± 14.0 | <0.05 | 87.3 ± 6.1 | 112.7 ± 9.0 | <0.05 | ||||
Tmax (h) | 1.3 ± 0.7 | 1.9 ± 0.2 | 0.18 | 0.5 | 0.5 | N.A. | ||||
AUC0-∞ (mg · h/l) | 69 ± 15.7 | 276.7 ± 33.3 | <0.05 | 216.3 ± 58.5 | 372.0 ± 58.0 | <0.05 | ||||
t1/2 (h) | 6.0 ± 1.7 | 8.0 ± 0.8 | 0.23 | 2.7 ± 0.7 | 4.1 ± 0.62 | 0.13 |
N.A., not applicable.