Excretion of radioactivity during 7 days after single and the last of 21 daily ocular doses of [3H]tafluprost ophthalmic solution (0.005%, w/v; 5 μl to both eyes) to intact male rats
Results are expressed as percentage of total radioactive dose and represent the mean of four animals per sex.
Biological Sample (Collection Period) | Single Dose | 21 Daily Doses | ||||||
|---|---|---|---|---|---|---|---|---|
| Male | Female | Male | Female | |||||
| Urine | (0-24 h) | 33.1 | 44.9 | 26.1 | 37.6 | |||
| (0-168 h) | 35.6 | 48.3 | 26.7 | 38.2 | ||||
| Feces | (0-24 h) | 48.6 | 32.7 | 57.2 | 42.9 | |||
| (0-168 h) | 58.7 | 46.4 | 58.2 | 43.7 | ||||
| Expired air | (0-168 h) | 0.3 | 1.1 | NM | NM | |||
| Total excretiona | (0-168 h) | 95.8 | 96.0 | 87.7 | 86.9 | |||
| Carcass | (168 h) | 2.1 | 2.2 | 0.8 | 0.8 | |||
| Total recovery | (168 h) | 97.9 | 98.2 | 88.5 | 87.7 | |||
NM, not measured.
↵ a Total excretion results includes cage washings.