Order of combination of enzymes in the metabolism of (S)-flurbiprofen by CYP2C9 and the effect of CPR
Mixing Scheme | Order of Addition | Effect of Saturating CPR |
|---|---|---|
| SeqAdd1 | 2C9_2D6_5 min_CPR_5 min_DLPC | No effect |
| SeqAdd2 | 2C9_CPR_5 min_2D6_5 min_DLPC | No effect |
| SeqAdd3 | 2D6_CPR_5 min_2C9_5 min_DLPC | Reduced inhibition |
| Allmix1 | 2C9_CPR_2D6_10 min_DLPC | Reduced inhibition |
| Allmix2 | 2C9_2D6_CPR_10 min_DLPC | Reduced inhibition |