Test Agents | Type of P450 Inhibitor | Concentration | Activity | % of Total |
---|---|---|---|---|
μM | nmol | |||
Control | 0.29 ± 0.02 | 100 | ||
Ellipticine | 1A | 10 | N.D. | 0 |
20 | N.D. | 0 | ||
Furafylline | 1A2 | 20 | 0.16 ± 0.04* | 55 |
α-Naphthoflavone | 1A | 20 | 0.07 ± 0.04* | 24 |
100 | N.D. | 0 | ||
SKF-525A | Nonspecific | 20 | 0.19 ± 0.01* | 66 |
100 | 0.18 ± 0.01* | 62 | ||
Ketoconazole | 3A | 20 | 0.17 ± 0.01* | 59 |
100 | 0.07 ± 0.04* | 24 | ||
Sulfaphenazole | 2C | 20 | 0.27 ± 0.02 | 93 |
|
| 100 | 0.26 ± 0.01 | 90 |
N.D., not detected.
↵* p < 0.05 compared with control.