Mean (S.D.) cumulative total radioactivity excreted through urine and feces (% of dose) after single-dose i.v. and oral administration of [14C]casopitant at target doses of 90 and 150 mg, respectively, to six healthy volunteers
Elapsed Time from Dose (h) | Intravenous | Oral | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Urine | Feces | Total | n | Urine | Feces | Total | |||||||
| 0-24 | 6 | 3.0 (0.2) | 0.2 (0.2) | 3.1 (0.2) | 6 | 3.3 (0.9) | 0.1 (0.1) | 3.3 (0.9) | ||||||
| 0-48 | 6 | 4.6 (0.2) | 11.9 (12.1) | 14.5 (12.0) | 6 | 4.4 (0.9) | 12.6 (10.2) | 17.0 (10.3) | ||||||
| 0-72 | 6 | 5.5 (0.2) | 32.7 (11.9) | 38.1 (12.0) | 6 | 5.3 (1.0) | 25.2 (12.0) | 30.5 (12.4) | ||||||
| 0-96 | 6 | 6.1 (0.2) | 43.7 (13.3) | 49.8 (13.5) | 6 | 5.8 (1.0) | 43.2 (5.1) | 49.0 (5.0) | ||||||
| 0-120 | 6 | 6.5 (0.2) | 56.9 (5.8) | 63.4 (5.9) | 6 | 6.1 (1.0) | 49.8 (4.2) | 56.0 (4.5) | ||||||
| 0-144 | 6 | 6.8 (0.2) | 62.7 (7.5) | 69.5 (7.7) | 6 | 6.4 (1.0) | 57.6 (4.5) | 64.1 (4.1) | ||||||
| 0-168 | 6 | 7.1 (0.2) | 67.3 (9.9) | 74.4 (10.1) | 6 | 6.6 (1.0) | 61.6 (6.0) | 68.2 (5.6) | ||||||
| 0-192 | 6 | 7.3 (0.2) | 74.7 (5.4) | 82.0 (5.4) | 6 | 6.8 (1.0) | 63.9 (4.9) | 70.7 (4.4) | ||||||
| 0-216 | 6 | 7.5 (0.2) | 77.1 (5.5) | 84.6 (5.5) | 6 | 7.0 (1.0) | 66.3 (5.7) | 73.2 (5.3) | ||||||
| 0-240 | 6 | 81.0 (7.1) | 88.6 (7.0) | 6 | 68.5 (5.3) | 75.4 (4.7) | ||||||||
| 0-264 | 6 | 82.9 (6.9) | 90.4 (6.9) | 6 | 69.4 (5.7) | 76.4 (5.2) | ||||||||
| 0-288 | 5 |
| 83.8 (7.3) | 91.3 (7.3) | 5 |
| 71.4 (6.2) | 78.3 (5.7) | ||||||