TABLE 4

Accuracy of the combined mathematical model and the two Simcyp models

Combined Model
Simcyp Steady-State Model
Simcyp Time-Based Model
All DDI
    GMFE 1.74 1.59a 1.47
    RMSE 4.58 5.07a 3.03
    Success rate 88 88 90
DDI >2×
    GMFE 1.88 1.64b 1.51
    RMSE
5.68
5.65b
3.60

  • ↵ a Including one outlier prediction value (mibefradil) yields values for GMFE and RMSE of 1.66 and 19.1, respectively.

  • ↵ b Including one outlier prediction value (mibefradil) yields values for GMFE and RMSE of 1.78 and 25.6, respectively.