Vitreal kinetic parameters of quinidine (0.75-μg dose) alone or in the presence of intravitreally coadministered verapamil (100 μg)
Verapamil solution (1 mg/ml in IPBS) was used as the perfusate. Values represent the mean ± S.D. (n = 4).
Kinetic Parameters | Quinidine | Quinidine + Intravitreal Verapamil |
|---|---|---|
| λz (min-1) | 0.0066 ± 0.0007 | 0.0043 ± 0.0002*** |
| AUC0-∞ (μg × min/ml) | 168 ± 56 | 180 ± 72 |
| CL (ml/min) | 0.0048 ± 0.0012 | 0.0046 ± 0.0014 |
| Vss (ml) | 0.41 ± 0.14 | 0.63 ± 0.27 |
| MRT∞ (min) | 83 ± 13 | 131 ± 16** |
| AUC100-540 (μg × min/ml) | 40 ± 0.03 | 56 ± 11* |
| AUC300-540 (μg × min/ml) | 7.73 ± 1.32 | 13.31 ± 2.28** |
| CL300-540 (ml/min) | 0.099 ± 0.017 | 0.057 ± 0.009** |