Inhibitors | IC50 Values | ||||
---|---|---|---|---|---|
5-LOX | 15-LOX- | 5-LOX/15-LOX Ratioa | |||
μM | |||||
CBD | 73.73 | 2.56 | 28.8 | ||
CBDM | >200 | 0.72 | 278 | ||
CBDD | >200 | 0.28 | 714 |
↵ a The ratio of the IC50 values for 5-LOX and 15-LOX can be used as an indication of the 15-LOX selectivity of inhibitors. A 5-LOX/15-LOX ratio of more than 1 indicates preferential 15-LOX selectivity.