TABLE 1

Mass/charge ratios and chemical structures of potential atazanavir metabolites used for knowledge-based metabolite screening

Metabolic Pathway
Proposed Atazanavir Products
[M + H]+
m/z
Hydroxylation Embedded Image 720-722
Oxygenation and dehydrogenation Embedded Image 718-720
Hydrolysis Embedded Image 646-648
N-Dealkylation Embedded Image 334-336
369-371
537-539
N-Glucuronidation Embedded Image 880-882
Oxygenation and glucuronidation
Embedded Image
896-898