IC50 Values in Human Liver Microsomes | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
α-Mang | β-Mang | Gartanin | 3-Iso | 8-Desoxy | 9-Hydroxy | ||||||
μM | |||||||||||
CYP1A2 | >20 | 5.99 | 1.13 | 5.94 | 0.57 | 0.50 | |||||
CYP2B6 | 2.89 | 10.6 | 1.60 | 5.23 | >20 | >20 | |||||
CYP2C8 | 0.88 | 8.39 | 6.28 | 0.64 | 1.85 | 14.1 | |||||
CYP2C9 | 1.14 | 0.77 | 4.66 | 0.48 | 3.80 | 17.6 | |||||
CYP2C19 | 4.54 | 4.45 | 4.75 | 3.99 | 3.41 | 9.18 | |||||
CYP2D6 | 7.36 | >20 | >20 | 6.00 | 10.7 | >20 | |||||
CYP2E1 | >20 | >20 | >20 | >20 | >20 | >20 | |||||
CYP3A4-M | 7.98 | >20 | 7.89 | 5.65 | 8.18 | >20 | |||||
CYP3A4-T | 2.49 | 6.39 | 4.94 | 2.23 | 1.75 | >20 |
α-Mang, α-mangostin; β-Mang, β-mangostin; 3-Iso, 3-isomangostin; 8-Desoxy, 8-desoxygartanin; 9-Hydroxy, 9-hydroxycalabaxanthone.