Ki values for the individual xanthone derivatives in human liver microsomes
(C) indicates that the inhibition data was fit to a competitive model; (M) indicates a linear-mixed model.
Ki Values in Human Liver Microsomes | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| α-Mang | β-Mang | Gartanin | 3-Iso | 8-Desoxy | 9-Hydroxy | ||||||
| μM | |||||||||||
| CYP1A2 | 3.58 (M) | 3.19 (M) | 2.63 (M) | ||||||||
| CYP2B6 | 1.91 (C) | 1.01 (C) | |||||||||
| CYP2C8 | 0.64 (C) | 0.66 (C) | 2.80 (C) | ||||||||
| CYP2C9 | 0.60 (C) | 0.34 (C) | 0.40 (C) | ||||||||
| CYP2C19 | |||||||||||
| CYP2D6 | |||||||||||
| CYP2E1 | |||||||||||
| CYP3A4-M | |||||||||||
| CYP3A4-T | 2.79 (C) |
|
| 3.23 (M) | 1.41 (C) |
| |||||
α-Mang, α-mangostin; β-Mang, β-mangostin; 3-Iso, 3-isomangostin; 8-Desoxy, 8-desoxygartanin; 9-Hydroxy, 9-hydroxycalabaxanthone.