Summary of in vivo hepatic intrinsic clearance of YM155
Parameters | Dose Level (mg/m2/day) | ||||
|---|---|---|---|---|---|
| 1.8 | 3.6 | 4.8 | |||
| CLnr (l/h/person)a | 31.9 | 50.8 | 48.2 | ||
| Well stirred model | |||||
| CLH int in vivo (l/h/person) | 39.2 | 95.0 | 84.0 | ||
| fp/RB · CLH int in vivo (l/h/person) | 50.4 | 122.2 | 108.0 | ||
| Dispersion model | |||||
| CLH int in vivo (l/h/person) | 32.9 | 66.8 | 60.9 | ||
| fp/RB · CLH int in vivo (l/h/person) | 42.3 | 85.9 | 78.3 | ||
↵ a These data were calculated data from the data cited from Tolcher et al., 2008.