TABLE 2

Mean pharmacokinetic parameter estimates governing APAP, AG, and AS disposition in in situ single-pass perfused livers from wild-type and Bcrp-deficient male and female mice

n = 3–4/group.

Mean Estimates (CV %)
Parameter
Wild-Type
Brcp-Deficient
CLup (ml/min)
    Male 5.63 (12.1) 5.60 (13.2)
    Female 5.79 (4.9) 5.55 (8.8)
Kperf, APAP (min-1)
    Male 0.468 (16.5) 0.588 (44.7)
    Female 0.525 (31.1) 0.564 (36.3)
Kgluc (min-1)*
    Male 0.183 (36.9) 0.199 (17.3)
    Female 0.121 (16.5) 0.119 (8.2)
Ksulf (min-1)*
    Male 0.007 (13.1) 0.009 (50.6)
    Female 0.026 (8.8) 0.018 (44.6)
Kperf, AG (min-1)
    Male 0.168 (45.4) 0.247 (22.5)
    Female 0.217 (49.3) 0.214 (77.3)
Kg1 (min-1)
    Male 0.044 (89.3) 0.104 (36.7)
    Female 0.093 (49.4) 0.092 (55.3)
Kbile, AG (min-1)*, **
    Male 0.014 (45.4) 0.001 (66.4)
    Female 0.002 (68.1) 0.001 (72.1)
Kperf, AS (min-1)*
    Male 0.379 (38.6) 0.271 (11.7)
    Female 0.663 (17.6) 0.634 (9.6)
Ks1 (min-1)*
    Male 0.048 (25.3) N.A.
    Female 0.017 (39.5) N.A.
Kbile, AS (min-1)*
    Male 0.107 (8.0) N.A.
    Female
0.043 (72.6)
N.A.

  • CV, coefficient of variation; N.A., not available.

  • ↵* p < 0.05, male vs. female.

  • ↵** p < 0.05, wild-type vs. Bcrp-deficient mice.