P450 Isoform | mRNA Level | Protein Level | Enzyme Activity | Reference | |
---|---|---|---|---|---|
First trimester of pregnancy | CYP1A1 | ++ | − | nd | Hakkola et al., 1996b |
CYP1A2 | + | nd | + | Schuetz et al., 1993 | |
CYP2A | − | − | nd | Pasanen et al., 1997 | |
CYP2B | − | − | nd | Bièche et al., 2007 | |
CYP2D6 | + | nd | nd | ||
CYP3A4 | + | + | nd | ||
CYP3A5 | + | + | nd | ||
CYP3A7 | + | + | nd | ||
Full-term placenta | CYP1A1 | ++ | + | + | Hakkola et al., 1996a |
CYP1A2 | − | nd | nd | ||
CYP2A6/7 | − | nd | nd | ||
CYP 2B6/7 | − | nd | nd | ||
CYP2C8–19 | − | nd | nd | ||
CYP2D6 | − | nd | nd | Pasanen et al., 1997 | |
CYP2E1 | + | − | − | ||
CYP2F1 | + | − | − | ||
CYP3A4 | + | − | − | ||
CYP3A5 | + | − | − | ||
CYP3A7 | − | − | − | ||
CYP4B1 | + | nd | nd | Nishimura et al., 2003 | |
CYP11A1 | ++ | nd | + | ||
CYP19 | ++ | nd | + | ||
JAR cells | CYP19 | + | + | + | Nakanishi et al., 2002 |
No data for other cytochromes | |||||
Jeg-3 cells | CYP1B1 | + | nd | nd | Pelkonen et al., 1984 |
CYP2C9 | + | nd | nd | Pavek et al., 2007 | |
CYP3A4 | + | nd | nd | Nakanishi et al., 2002 | |
CYP19 | + | + | + | Samson et al., 2009 | |
3β-HSD1 | + | nd | + | Smuc and Rizner, 2009 | |
17β-HSD1–12 | + | nd | + | ||
BeWo cells | CYP1A1 | + | + | + | Avery et al., 2003 |
CYP1A2 | + | + | + | ||
CYP2C9 | + | nd | nd | Pavek et al., 2007 | |
CYP3A4 | + | nd | nd | Nakanishi et al., 2002 | |
CYP19 | + | + | + |
nd, no data available; HSD, hydroxysteroid dehydrogenase type 1.
+, positive signal.
++, strong positive signal.
−, negative result.