Ordinal logistic regression analysis of daily dose and covalent binding in HLMs and human hepatocytes in vitro and rat liver in vivo
Whole-Model Test | Analysis of Maximum Likehood Estimation | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Test Systems | Logit r2 | β0 SAFE | β0 WNG | β1 (Daily Dose) | β2 (Covalent Binding) | |||||||||||||||||||
| Estimate | S.E. | P Value | Estimate | S.E. | P Value | Estimate | S.E. | P Value | Estimate | S.E. | P Value | |||||||||||||
| HLMs | 0.385 | 7.27 | 1.89 | 0.0001 | 10.8 | 2.39 | <0.0001 | -2.82 | 0.68 | <0.0001 | -1.57 | 0.48 | 0.0011 | |||||||||||
| Human hepatocytes | 0.499 | 9.54 | 2.59 | 0.0002 | 13.4 | 3.27 | <0.0001 | -3.89 | 1.01 | 0.0001 | -2.36 | 0.71 | 0.0009 | |||||||||||
| Rat liver in vivo | 0.385 | 5.51 | 1.66 | 0.0009 | 8.94 | 2.13 | <0.0001 | -2.06 | 0.61 | 0.0008 | -2.36 | 0.71 | 0.0009 | |||||||||||