Parameter (Unit) | Definition | Estimate |
---|---|---|
k12 (min−1) | Diffusion rate constant of plasma nitrite from the administration site to the systemic circulation | 2.13 |
k45 (min−1) | Diffusion rate constant of plasma nitrate from the administration site to the systemic circulation | 0.306 |
k23 (min−1) | Distribution rate constant from the blood to the tissue compartment | 6.04 |
k32 (min−1) | Distribution rate constant from the tissue to the blood compartment | 0.467 |
k26 (min−1) | Uptake rate constant of plasma nitrite into red blood cells | 0.256 |
k75 (min−1) | Diffusion rate constant of nitrate from red blood cells to plasma | 0.013 |
k14 (min−1) | Formation rate constant of plasma nitrate from nitrite at the administration site | 0.238 |
k25 (min−1) | Formation rate constant of nitrate from nitrite in plasma | 0.016 |
k67 (min−) | Formation rate constant of nitrate from nitrite in red blood cells | 0.808 |
k68 (min−1) | Formation rate constant of iron-nitrosyl hemoglobin | 2.02 |
k69a (min−1) | Formation rate constant of methemoglobin during the first infusion | 0.155 |
K69b (min−1) | Formation rate constant of methemoglobin during the second infusion | 0.090 |
k50 (min−1) | Elimination rate constant of plasma nitrate | 0.014 |
k80 (min−1) | Elimination rate constant of iron-nitrosyl hemoglobin | 0.161 |
k90 (min−1) | Elimination rate constant of methemoglobin | 0.043 |
Va (liters) | Volume of distribution for plasma nitrite and nitrate at the administration site | 0.071a |
Vp (liters) | Volume of distribution for plasma nitrite and nitrate in the systemic circulation | 2.76 |
VRBC (liters) | Volume of distribution for red blood cell nitrite and methemoglobin | 0.214 |
VNOHb (liters) | Volume of distribution for iron-nitrosyl hemoglobin | 6.93 |
↵a Fixed parameter value.