Effect of monoclonal anti-P450 antibodies on the formation of H1, H4, and H6 from nomifensine in human liver microsomes
| mAbs to P450 | Inhibition | ||
|---|---|---|---|
| Formation of H1 | Formation of H4 | Formation of H6 | |
| % | |||
| Anti-CYP1A2 | 7.8 ± 0.7 | 27 ± 3.1 | 4.6 ± 0.8 |
| Anti-CYP2B6 | 8.2 ± 0.9 | 12 ± 0.9 | 63 ± 1.4 |
| Anti-CYP2C19 | 11 ± 1.2 | 22 ± 1.8 | 9.9 ± 1.2 |
| Anti-CYP3A4 | 62 ± 2.6 | 0 | 0 |
| Anti-CYP1A2, anti-2B6, anti-2C19, anti-3A4 | 79 ± 1.0 | 57 ± 0.8 | 74 ± 0.5 |