TABLE 3

AUC0–t values of berberine and phase I metabolites after oral or intravenous administration

Data are presented as mean ± SD. n = 5 each.

BerberineM1M2M3
ng · h/ml
Intragastric
    Enzyme-digested65.1 ± 3.2*441.5 ± 109.3**178.6 ± 53.913.9 ± 2.4
    Undigested73.5 ± 7.383.3 ± 29.700
Intravenous
    Enzyme-digested631.1 ± 77.6234.7 ± 35.81040.2 ± 145.2**82.7 ± 15.9**
    Undigested656.5 ± 32.2198.1 ± 53.0149.0 ± 45.221.8 ± 1.8

  • ↵* P < 0.05.

  • ↵** P < 0.01 vs. undigested.