AUC0–t values of several important tissues and tissue/plasma ratios of berberine and its phase I metabolites after oral dosage
n = 5 each.
| Metabolite | AUC0–t | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Plasma | Liver | L/P | Heart | H/P | Kidney | K/P | Lung | Lu/P | Spleen | S/P | Brain | B/P | |
| ng · h/ml | ng · h/ml | ng · h/ml | ng · h/ml | ng · h/ml | ng · h/ml | ||||||||
| M1 | |||||||||||||
| Undigested | 22.2 | 1108.5 | 50.0 | 44.5 | 2.0 | 91.9 | 4.1 | ||||||
| Digested | 631.1 | 1036.3 | 1.6 | 42.4 | 0.1 | 98.7 | 0.2 | ||||||
| M2 | |||||||||||||
| Undigested | 60.4 | 2001.3 | 33.1 | 85.1 | 1.4 | 58.5 | 1.0 | ||||||
| Digested | 683.1 | 2479.1 | 3.6 | 100.1 | 0.1 | 68.6 | 0.1 | ||||||
| M3 | |||||||||||||
| Undigested | 0.6 | 106.7 | 171.4 | 49.5 | 79.5 | 17.2 | 27.7 | ||||||
| Digested | 80.6 | 296.4 | 3.7 | 81.0 | 1.0 | 38.1 | 0.5 | ||||||
| Berberine | |||||||||||||
| Undigested | 21.6 | 1645.9 | 76.3 | 120.0 | 5.6 | 49.6 | 2.3 | 31.2 | 1.4 | 50.2 | 2.3 | 9.9 | 0.5 |
| Digested | 25.1 | 1687.5 | 67.1 | 147.0 | 5.8 | 57.8 | 2.3 | 35.1 | 1.4 | 69.4 | 2.8 | 12.5 | 0.5 |
L/P, liver/plasma ratio; H/P, heart/plasma ratio; K/P, kidney/plasma ratio; Lu/P, lung/plasma ratio; S/P, spleen/plasma ratio.