Calculated parameters for irreversible inactivation
The kinact and K′app values for each CBPM were obtained by nonlinear curve fitting of Fig. 3 into eq. 1
| CBPM | Human Liver Cytosol | Rat Liver Cytosol | ||||
|---|---|---|---|---|---|---|
| kinact | K′app | kinact/K′app | kinact | K′app | kinact/K′app | |
| min−1 | μM | μM−1 · min−1 | min−1 | μM | μM−1 · min−1 | |
| PAPM | 9.66 | 51 | 0.189 | 5.65 | 29 | 0.192 |
| MEPM | 7.34 | 166 | 0.044 | 5.03 | 129 | 0.039 |
| DRPM | 6.92 | 142 | 0.049 | 4.92 | 148 | 0.033 |
| BIPM | 0.013 | 0.011 | ||||