Apparent first-order degradation rate constants and half-lives of PP in ocular tissue homogenates (1 mg/ml protein content)
Values represent means ± S.D. (n = 4).
| Drug/Kinetic Parameters | Control | Aqueous Humor | Vitreous Humor | Iris-Ciliary Body | RPE/Choroid |
|---|---|---|---|---|---|
| k (×103 min−1) | 0.36 ± 0.03 | 22.5 ± 4.0 | 0.83 ± 0.02 | 2.9 ± 0.09 | 3.17 ± 0.05 |
| t1/2 (min) | 1933 ± 160 | 31 ± 6.0 | 835 ± 17.0 | 239 ± 8.0 | 218 ± 4.0 |