Summary of micafungin saturable and nonsaturable uptake kinetics in SCRH and SCHH
Mean ± S.D. kinetic parameters reflecting micafungin uptake were obtained by nonlinear regression using a model incorporating both a saturable (Michaelis-Menten) component and a nonsaturable (linear) component. Taurocholate uptake clearance values in the two SCRH cultures used here were 22.5 ± 4.8 and 28.5 ± 2.6 μl/(min · mg protein).
| Kinetic Parameter | Rat | Human |
|---|---|---|
| Km (μM) | 39 ± 6 | 40 ± 5 |
| Vmax [pmol/(min · mg protein)] | 591 ± 24 | 814 ± 248 |
| Cld [μl/(min · mg protein)] | 3.8 ± 0.3 | 3.3 ± 0.5 |
| Vmax/Km [μl/(min · mg protein)] | 15.2 ± 4.4 | 20.5 ± 2.2 |