Inhibition of KTZ on APZ metabolite formation in liver and small intestinal microsomes from humans and cynomolgus monkeys
Activity was measured at a substrate concentration of 100 μM. IC50 values are calculated for duplicate incubations.
| Metabolite | IC50 | |||
|---|---|---|---|---|
| Liver Microsomes | Intestinal Microsomes | |||
| Human | Monkey | Human | Monkey | |
| μM | ||||
| 1′-OH APZ | 0.071 | 0.086 | 0.027 | 0.018 |
| 4-OH APZ | 0.035 | 0.069 | 0.026 | 0.017 |