Activity [pmol/(h · million cells)] | | | | | | | | |
Control | 994 ± 152 | 1557 ± 450 | 250 ± 12 | 307 ± 35 | 336 ± 60 | 235 ± 9 | 193 ± 18 | 351 ± 21 |
10 μM Rifampicin | 15699 ± 1856 | 25412 ± 2333 | 3940 ± 628 | 5644 ± 198 | 5522 ± 1038 | 3286 ± 523 | 1962 ± 599 | 9319 ± 908 |
30 μM Phenytoin | 6507 ± 873 | 9396 ± 266 | 637 ± 74 | 897 ± 73 | 936 ± 212 | 423 ± 102 | 336 ± 74 | 1427 ± 250 |
30 μM Carbamazepine | 4260 ± 535 | 7070 ± 487 | 532 ± 93 | 732 ± 83 | 1234 ± 106 | 442 ± 113 | 420 ± 76 | 1315 ± 80 |
Fold | | | | | | | | |
Control | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
10 μM Rifampicin | 15.8 ± 3.1 | 16.3 ± 5 | 15.8 ± 2.6 | 18.4 ± 2.2 | 16.4 ± 4.3 | 14 ± 2.3 | 10.2 ± 3.3 | 26.6 ± 3 |
30 μM Phenytoin | 6.5 ± 1.3 | 6 ± 1.8 | 2.5 ± 0.3 | 2.9 ± 0.4 | 2.8 ± 0.8 | 1.8 ± 0.4 | 1.7 ± 0.4 | 4.1 ± 0.8 |
30 μM Carbamazepine | 4.3 ± 0.8 | 4.5 ± 1.4 | 2.1 ± 0.4 | 2.4 ± 0.4 | 3.7 ± 0.7 | 1.9 ± 0.5 | 2.2 ± 0.4 | 3.7 ± 0.3 |
%RIF | | | | | | | | |
Control | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
10 μM Rifampicin | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
30 μM Phenytoin | 37.5 ± 7.7 | 32.9 ± 3.9 | 10.5 ± 2.7 | 11.1 ± 1.6 | 11.6 ± 4.8 | 6.2 ± 3.5 | 8.1 ± 5.1 | 12.0 ± 3.0 |
30 μM Carbamazepine | 22.2 ± 4.7 | 23.1 ± 3.6 | 7.7 ± 2.9 | 8 ± 1.7 | 17.3 ± 4.2 | 6.8 ± 3.9 | 12.9 ± 6.2 | 10.8 ± 1.4 |