TABLE 1

Metabolites for the 27 compounds used in this analysis and their amount in human circulation and excreta

The amount in circulation or excreta are included only if values exceed 10%.

Compound Name	In Vivo Human Metabolites	Phase 1 or 2	Primary or Secondary Metabolite	Percentage in Excreta	Percentage of Circulating Radioactivity
Gemcabene	Gemcabene glucuronide	2	1	44
Avasimibe	Dehydrogenated avasimibe	1	1		16
	Hydroxyavasimibe	1	1		10
Pagoclone	Hydroxypagoclone	1	1		65
Axitinib	Hydroxyaxitinib	1	1	11
	Axitinib sulfoxide	1	1		16
	Axitinib glucuronide	2	1		50
Capravirine	Hydroxycapravirine sulfoxide	1	2	11
	Hydroxycapraivirinesulfone N-oxide	1	2	10
CJ-13610	CJ-13610 sulfoxide	1	1	36	17
	CJ-13610 sulfone	1	2	21	10
Traxoprodil	Traxoprodil methoxy sulfate	2	2	40	28
	Traxoprodil methoxy glucuronide	2	2	10	18
CP-122721	Desmethyl CP-122721 glucuronide	2	2	27	14
	N-Dealkylated CP-122721 glucuronide	2	2	11
	DesmethylhydroxyCP-122721 glucuronide	2	2		25
	5-Trifluoromethoxysalicylic acid	1	2		56
Tofimulast	Dihydroxytofimulast	1	2	23	14
	Ring-opened tofimulast	1	2		33
	Desthiophene tofimulast	1	2		13
Lasofoxifene	Lasofoxifene glucuronide	2	1		22
Capromorelin	Carboxylic acid of capromorelin	1	2	11	14
	O-Debenzyl hydroxycapromorelin	1	2		12
	Carboxylic acid of N-desmethyl-O-debenzylcapromorelin	1	2		12
	N-Desmethyl-O-debenzyl hydroxycapromorelin	1	2		15
Torcetrapib	Bistrifluoromethyl benzoic acid	1	2	50	50
	7-Trifluoromethylquinaldic acid	1	2	29	63
CP-533536	Hydroxy CP-533536	1	1	70
	CP-533536 sulfate	2	1	11
CP-547632	N-Dealkyl CP-547632	1	1		15
Zoniporide	Hydroxyzoniporide	1	1	52	64
	Carboxylic acid of zoniporide	1	2	17
Celecoxib	Carboxylic acid of celecoxib	1	2	73	20
	Celecoxib glucuronide	2	2		15
CP-690550	Hydroxy CP-690550	1	1	20	12
	Dihydroxy CP-690550	1	2	12	12
	Dihydroxy CP-690550 glucuronide	2	2	11	13
Ziprasidone	Ziprasidone sulfoxide	1	1	18	69
	S-Methyldihydroziprasidone	1	2	18	69
	N-Dealkylziprasidone S-oxide	1	2	11	21
	N-Dealkylziprasidone sulfone	1	2	11	21
Sunepitron	Hydroxysunepitron	1	1	17	61
Trovafloxacin	Trovafloxacin glucuronide	2	1	13	22
Linezolid	Ring-opened linezolid	1	2	45
	Ring-opened linezolid	1	2	10
Sunitinib	N-Dealkyl sunitinib	1	1	32	21
Irinotecan	Ring-opened carboxylic acid	1	2	11
Delavirdine	N-Dealkyldelavirdine	1	1	46	25
	Depyridinyl delavirdine	1	1	38
Valdecoxib	Hydroxyvaldecoxib glucuronide	2	2	23
	Valdecoxib N-glucuronide	2	1	20
Eplerenone	6β-Hydroxyeplerenone	1	1	32	16
	6β,21-Dihydroxeplerenone	1	2	21
Maraviroc	Hydroxymethyl maraviroc	1	1	13
	N-Desalkyl maraviroc	1	2		22
	N-Desalkyl hydroxymethyl maraviroc	1	2		11